THE ENDOSOME LOCALIZED ARF-GAP AGAP1 MODULATES DENDRITIC SPINE MORPHOLOGY DOWNSTREAM OF THE NEURODEVELOPMENTAL DISORDER FACTOR DYSBINDIN

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin

AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1).Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which suggests a role in endosome-dependent traffic.In additi

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Transient Turing patterns in a morphogenetic model

One of the most surprising mechanisms to explain the symmetry breaking phenomenon linked to pattern formation is known as Turing instabilities.These patterns are self-organising spatial structures resulting from the interaction of at least two diffusive species in specific conditions.The ideas of Turing have been used extensively in the specialised

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